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Inside Your Dog’s Stress Response

The Chemistry of Calm

Introducing the 3 main hormones that interact to guide emotions...

Cortisol

The "stress" hormone that controls the ability to cope with physical and emotional stress.

Serotonin

The "happy" hormone that plays a role in regulating sleep, mood, and behaviour.

Dopamine

The "feel-good" hormone that controls the reward system that boosts motivation.

Stressful moments are a natural part of a dog’s world. Some of these stressors may stem from separation from loved ones, moving to a new home, loud sounds like fireworks, or vet visits.

Calm routines, positive reinforcement, and thoughtfully chosen tools provided by humans can help create a sense of safety and a steadier return to emotional balance.

Calm routines, positive reinforcement, and thoughtfully chosen tools provided by humans can help create a sense of safety and a steadier return to emotional balance.

What matters most is how they learn to navigate emotions. With patience, consistency, and the right support, dogs can be guided to respond with greater ease and confidence.

References

1. Bacqué-Cazenave, J., Bharatiya, R., Barrière, G., Delbecque, J. P., Bouguiyoud, N., Di Giovanni, G., Cattaert, D., & De Deurwaerdère, P. (2020). Serotonin in Animal Cognition and Behavior.International journal of molecular sciences,21(5), 1649. https://doi.org/10.3390/ijms21051649

2. Cocco R, Arfuso F, Giannetto C, et al. A Preliminary Study on the Interplay between the Serum Levels of Neurotransmitters and Thyroid Hormones for the Evaluation of the Behavioral Phenotype of Dogs.Animals (Basel). 2023;13(3):411. Published 2023 Jan 26. doi:10.3390/ani13030411

3. Mârza, S. M., Munteanu, C., Papuc, I., Radu, L., Diana, P., & Purdoiu, R. C. (2024). Behavioral, Physiological, and Pathological Approaches of Cortisol in Dogs.Animals,14(23), 3536. https://doi.org/10.3390/ani14233536

4. Quinn R, Masters S, Starling M, White PJ, Mills K, Raubenheimer D and McGreevy P (2025) Functional significance and welfare implications of chewing in dogs (Canis familiaris).Front. Vet. Sci. 12:1499933. doi: 10.3389/fvets.2025.1499933

5. Salavati, S. , Mogheiseh, A. , Nazifi, S. , Amiri, A. , & Nikahval, B. (2023). The effects of melatonin on the concentrations of inflammatory cytokines and proteins, serotonin, cortisol and melatonin in ovariohysterectomised female dogs. Veterinary Medicine and Science, 9, 1103–1113. 10.1002/vms3.1112